• A novel regulatory mechanism for human interferon lambda has been defined

  • A new graduate student begins her work towards an M.S. at HUMIGEN, graduation expected 2013

  • HUMIGEN opens two new research laboratories, in Lymphocyte Signaling and Cellular Immunology

  • HUMIGEN begins recruiting SLE patients for a novel biomarker discovery study

  • A HUMIGEN Research Associate graduates May 2011 with an M.S. in Molecular Pathology and Immunology

  • HUMIGEN begins recruiting asthma patients for a novel biomarker discovery study

  • A new soluble variant of the human IL-23 receptor inhibits the development of human Th17 cells

  • Two graduate students are working towards their M.S. in HUMIGEN, graduation expected 2012

  • HUMIGEN begins recruiting IBD patients for a novel biomarker discovery study

  • A novel feedback loop between the Th2 response and interferon lambda is mediated by monocytes

  • A new Ph.D. student begins work in HUMIGEN research laboratories

Abstracts & Presentations



The Crohn’s disease protective SNP rs11209026 allele “A” mediates alternative splicing in human IL23R transcription. Yu RY and Gallagher G. 2010 Digestive Disease Week, New Orleans, LA, May 1-5, 2010.  

A naturally-occurring soluble antagonist of human IL-23 inhibits the development and in-vitro function of human TH17 cells. Yu RY and Gallagher G. 2010 Digestive Disease Week New Orleans, LA, May 1-5, 2010.  

The Crohn’s disease protective SNP rs11209029 mediates alternative splicing human IL23R. Gallagher G, Brazaitis J, and Yu RY. 97th Annual Meeting of the American Association of Immunologists, Baltimore, MD, May 7-11, 2010.  

Regulation of type-III interferons in airway epithelial cells. Gallagher G, Siegel R, and Eskdale J. 97th Annual Meeting of the American Association of Immunologists (AAI), Baltimore, MD, May 7-11, 2010.  

A naturally antagonist of human IL-23 inhibits the development  and function of human Th17 cells. Gallagher G and Yu RY. 97th Annual Meeting of the American Association of Immunologists (AAI), Baltimore, MD, May 7-11, 2010.  

Characterization of IFN-λ1 (IL-29) gene regulation and analysis of inter-individual variation of IFN-λ1 levels. Siegel R, Eskdale J, and Gallagher G. 96th Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, May 8-12, 2009.  

Modulation of human pDC function by IFN-λ1 (IL-29). Gallagher GE, Gallagher G, and Nick Megjugorac. 96th Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, May 8-12, 2009.  

Reciprocal control of IL-4 and IFN-λ1 (IL-29):  mechanisms for the control of Th2 polarization. Megjugorac N, Dai J, Gallagher GE, and Gallagher G. 96th Annual Meeting of the American Association of Immunologists (AAI), Seattle, WA, May 8-12, 2009.  

Molecular Mechanism of Sex-specific Association of Interferon Regulatory Factor 4 with Childhood Acute Lymphoblastic Leukemia (ALL). Do T, Davis C, Ucisik-Akkaya, E, Morrison B, and Dorak MT. 35th Annual  American Society for Histocompatibility and Immunogenetics Meeting (ASHI), San Francisco, CA, November 2-6, 2009.  

Immunoregulatory Gene Polymorphisms and Childhood Acute Lymphoblastic Leukemia (ALL) Susceptibility. Ucisik-Akkaya E, Davis C, Do T, and Dorak MT. 35th Annual American Society for Histocompatibility and Immunogenetics Meeting (ASHI), San Francisco, CA, November 2-6, 2009.  

Polymorphisms of Iron Regulatory Genes with Immune Functions are Associated with Childhood Acute Lymphoblastic Leukemia (ALL ) Susceptibility. Davis C, Ucisik-Akkaya E, Do T, and Dorak MT.
35th Annual  American Society for Histocompatibility and Immunogenetics Meeting (ASHI), San Francisco, CA, November 2-6, 2009.
 

Polymorphisms of iron-related genes and childhood leukemia risk. Davis C, Do T, Dorak MT. 58th Annual Meeting of the American Society for Human Genetics. Philadelphia, PA, November 11-15, 2008.  

Genetic associations in childhood leukemia and interactions with sex. Dorak MT, Ucisik-Akkaya E, Davis C, Morrison BA, Do T. 58th Annual Meeting of the American Society for Human Genetics. Philadelphia, PA, November 11-15, 2008.  

Markers for sex-specific prenatal selection. Ucisik-Akkaya E, Davis C, Morrison BA, Do T, Dorak MT. 58th Annual Meeting of the American Society for Human Genetics. Philadelphia, PA, November 11-15, 2008.  

TP53 R72P polymorphism and childhood leukemia susceptibility. Do T, Ucisik-Akkaya E, Davis C, Morrison BA, Dorak MT 58th Annual Meeting of the American Society for Human Genetics. Philadelphia, PA, November 11-15, 2008.  

Update on conserved extended haplotypes and possible identification of the ancestral MHC haplotype. Ucisik-Akkaya E, Morrison BA, Davis C, Do T, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

An analysis of the extended HLA class I region gene HFE and flanking genes. Davis C, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

Similarities between multiple sclerosis and childhood leukemia HLA complex associations. Morrison BA, Ucisik-Akkaya E, Flores H, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

HLA class III region genes HSPA1L/A/B polymorphisms and childhood leukemia risk. Ucisik-Akkaya E, Morrison BA, Gorodezky C, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

Extended HLA class II region genes RXRB and DAXX polymorphisms in childhood leukemia. Ucisik-Akkaya E, Morrison BA, Alaez C, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

MHC associations in childhood leukemia: identification of heterozygote advantage. Morrison BA, Davis C, Ucisik-Akkaya E, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

Polymorphisms of natural killer cell receptor NKG2D and childhood leukemia susceptibility. Ucisik-Akkaya E, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

Two proto-oncogenes located in the HLA class III region (PBX2 and NOTCH4) show associations with childhood leukemia. Morrison BA, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

Complete sequencing of HLA-DQA1 UTR and correlations with ancestral lineages. Morrison BA, Dorak MT. 34th Annual Meeting of the American Society for Histocompatibility and Immunogenetics (ASHI). Toronto, Ontario Canada, October 27-31, 2008.  

IFN-λ1 (IL-29) Suppresses the Differentiation of Human Naive and Memory Th2 Cells Without Inhibiting their Proliferation. Dai J, Megjugorac N, Gallagher G 7th Joint Conference of the International Society for Interferon and Cytokine Research and International Cytokine Society, Montreal Quebec, Canada, October 12-16, 2008.  

Coordinated Expression of IFN-λ1 and IL-4, a Novel Feedback Loop Leading to the Reduction of Th2 Responses. Gallagher G, Gallagher GE, Dai J, Megjugorac N. 7th Joint Conference of the International Society for Interferon and Cytokine Research and International Cytokine Society, Montreal Quebec, Canada, October 12-16, 2008.  

Production of, and Response to, IFN-λ1 by Plasmacytoid Dendritic Cells. Megjugorac N, Gallagher GE, Gallagher G. 7th Joint Conference of the International Society for Interferon and Cytokine Research and International Cytokine Society, Montreal Quebec, Canada, October 12-16, 2008.