HUMIGEN members are active in research. Although HUMIGEN was formed in 2007, we have brought a strong breadth and depth of
expertise to the Institute. Here are our primary research papers from the last five years.
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2007
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2006
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2005
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2004
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2003
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2002 |
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2007
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Dorak MT, Pearce MS, Hammal DM, McNally RJ, Parker L. Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom).
Cancer Causes Control. 2007 Mar;18(2):219-28. |
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Jordan WJ, Eskdale J, Boniotto M, Rodia M, Kellner D, Gallagher G. Modulation of the human cytokine response by interferon λ-1 (IFN-λ1/IL-29). Genes Immun. 2007 Jan;8(1):13-20.
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Jordan WJ, Eskdale J, Srinivas S, Pekarek V, Kelner D, Rodia M, Gallagher G. Human interferon λ-1 (IFN-λ1/IL-29) modulates the Th1/Th2 response. Genes Immun. 2007 Apr;8(3):254-61. |
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Pekarek V, Srinivas S, Eskdale J, Gallagher G. Interferon λ-1 (IFN-λ1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-Γ-independent manner. Genes Immun. 2007 Mar;8(2):177-80. |
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2006
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Boniotto M, Jordan WJ, Eskdale J, Tossi A, Antcheva N, Crovella S, Connell ND, Gallagher G. Human Β-defensin 2 induces a vigorous cytokine response in peripheral blood mononuclear cells.
Antimicrob Agents Chemother. 2006 Apr;50(4):1433-41. |
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Dorak MT, Shao W, Machulla HK, Lobashevsky ES, Tang J, Park MH, Kaslow RA. Conserved extended haplotypes of the major histocompatibility complex: further characterization.
Genes Immun. 2006 Sep;7(6):450-67.
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Liebel F, Lyte P, Garay M, Babad J, Southall MD. Anti-inflammatory and anti-itch activity of sertaconazole nitrate. Arch Dermatol Res. 2006 Sep;298(4):191-9. |
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Pearce MS, Hammal DM, Dorak MT, McNally RJ, Parker L. Paternal occupational exposure to electro-magnetic fields as a risk factor for cancer in children and young adults: A case-control study from the North of England. Pediatr Blood Cancer. 2006 Aug 29;49(3):280-286 |
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Shao W, Lazaryan A, Dorak MT, Penman-Aguilar A, Wilson CM, Margolick JB, Goedert JJ, Prins M, Tang J, Kaslow RA. Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression. AIDS. 2006 Aug 1;20(12):1583-90. |
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2005
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Dorak MT, Yee LJ, Tang J, Shao W, Lobashevsky ES, Jacobson LP, Kaslow RA. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.
J Med Virol. 2005 Jul;76(3):302-10. |
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Jordan WJ, Eskdale J, Boniotto M, Lennon GP, Peat J, Campbell JD, Gallagher G. Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10. Eur J Immunol. 2005 May;35(5):1576-82. |
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Jordan WJ, Eskdale J, Lennon GP, Pestoff R, Wu L, Fine DH, Gallagher G. A non-conservative, coding single-nucleotide polymorphism in the N-terminal region of lactoferrin is associated with aggressive periodontitis in an African-American, but not a Caucasian population. Genes Immun. 2005 Oct;6(7):632-5. |
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Swiggard WJ, Baytop C, Yu JJ, Dai J, Li C, Schretzenmair R, Theodosopoulos T, O'Doherty U. Human immunodeficiency virus type 1 can establish latent infection in resting CD4+ T cells in the absence of activating stimuli. J Virol. 2005 Nov;79(22):14179-88.
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Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme.
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2040-4.
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2004
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Boniotto M, Hazbon MH, Jordan WJ, Lennon GP, Eskdale J, Alland D, Gallagher G. Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease.
Clin Diagn Lab Immunol. 2004 Jul;11(4):766-9. |
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Boniotto M, Ventura M, Eskdale J, Crovella S, Gallagher G. Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. Genet Test. 2004 Fall;8(3):325-7. |
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Dai J, Megjugorac NJ, Amrute SB, Fitzgerald-Bocarsly P. Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.
J Immunol. 2004 Aug 1;173(3):1535-48. |
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Dorak MT, Tang J, Penman-Aguilar A, Westfall AO, Zulu I, Lobashevsky ES, Kancheya NG, Schaen MM, Allen SA, Kaslow RA. Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.
Lancet. 2004 Jun 26;363(9427):2137-9.
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Gallagher G, Eskdale J, Jordan W, Peat J, Campbell J, Boniotto M, Lennon GP, Dickensheets H, Donnelly RP. Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses.
Int Immunopharmacol. 2004 May;4(5):615-26. |
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Shao W, Tang J, Dorak MT, Song W, Lobashevsky E, Cobbs CS, Wrensch MR, Kaslow RA. Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification. Tissue Antigens. 2004 Sep;64(3):286-92. |
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Shao W, Lobashevsky ES, Kaslow RA, Dorak MT. MICA intron 1 sequences of conserved extended HLA haplotypes: implications for sequencing-based typing. Genes Immun. 2004 Aug;5(5):371-4. |
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Uyar FA, Dorak MT, Saruhan-Direskeneli G. Human leukocyte antigen-A, -B and -C alleles and human leukocyte antigen haplotypes in Turkey: relationship to other populations.
Tissue Antigens. 2004 Aug;64(2):180-7. |
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2003
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Behrens EM, Gadue P, Gong SY, Garrett S, Stein PL, Cohen PL. The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur J Immunol. 2003 Aug;33(8):2160-7. |
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Dorak MT, Tang J, Tang S, Penman-Aguilar A, Coutinho RA, Goedert JJ, Detels R, Kaslow RA. Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men. J Infect Dis. 2003 Sep 15;188(6):856-63.
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Izaguirre A, Barnes BJ, Amrute S, Yeow WS, Megjugorac N, Dai J, Feng D, Chung E, Pitha PM, Fitzgerald-Bocarsly P. Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells. J Leukoc Biol. 2003 Dec;74(6):1125-38. |
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Johnson D, Kan SH, Oldridge M, Trembath RC, Roche P, Esnouf RM, Giele H, Wilkie AO. Missense mutations in the homeodomain of HOXD13 are associated with brachydactyly types D and E.
Am J Hum Genet. 2003 Apr;72(4):984-97.
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Kan SH, Johnson D, Giele H, Wilkie AO. An acceptor splice site mutation in HOXD13 results in variable hand, but consistent foot malformations. Am J Med Genet A. 2003 Aug 15;121(1):69-74.
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Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, Langer JA, Sheikh F, Dickensheets H, Donnelly RP. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nat Immunol. 2003 Jan;4(1):69-77.
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Machulla HK, Batnasan D, Steinborn F, Uyar FA, Saruhan-Direskeneli G, Oguz FS, Carin MN, Dorak MT. Genetic affinities among Mongol ethnic groups and their relationship to Turks. Tissue Antigens. 2003 Apr;61(4):292-9.
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Oguz FS, Kalayoglu S, Diler AS, Tozkir H, Sargin D, Carin M, Dorak MT. HLA system affects the age-at-onset in chronic myeloid leukemia. Am J Hematol. 2003 Aug;73(4):256-62.
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2002
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Anaya JM, Correa PA, Herrera M, Eskdale J, Gallagher G. Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren's syndrome and is linked to IL-10 gene polymorphism.
J Rheumatol. 2002 Sep;29(9):1874-6. |
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Dorak MT, Folayan GO, Niwas S, van Leeuwen DJ, Yee LJ, Tang J, Kaslow RA. C-C chemokine receptor 2 and C-C chemokine receptor 5 genotypes in patients treated for chronic hepatitis C virus infection. Immunol Res. 2002;26(1-3):167-75. |
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Dorak MT, Lawson T, Machulla HK, Mills KI, Burnett AK. Increased heterozygosity for MHC class II lineages in newborn males.
Genes Immun. 2002 Aug;3(5):263-9. |
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Dorak MT, Oguz FS, Yalman N, Diler AS, Kalayoglu S, Anak S, Sargin D, Carin M. A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL. Leuk Res. 2002 Jul;26(7):651-6. |
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Kan SH, Elanko N, Johnson D, Cornejo-Roldan L, Cook J, Reich EW, Tomkins S, Verloes A, Twigg SR, Rannan-Eliya S, McDonald-McGinn DM, Zackai EH, Wall SA, Muenke M, Wilkie AO. Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis.
Am J Hum Genet. 2002 Feb;70(2):472-86.
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de Jong BA, Westendorp RG, Eskdale J, Uitdehaag BM, Huizinga TW. Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis. Hum Immunol. 2002 Apr;63(4):281-5. |
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Kotb M, Norrby-Teglund A, McGeer A, El-Sherbini H, Dorak MT, Khurshid A, Green K, Peeples J, Wade J, Thomson G, Schwartz B, Low DE. An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections.
Nat Med. 2002 Dec;8(12):1398-404. |
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Oguz FS, Yalman N, Diler AS, Oguz R, Anak S, Dorak MT. HLA-DRB1*15 and pediatric aplastic anemia.
Haematologica. 2002 Jul;87(7):772-4.
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Sabek O, Dorak MT, Kotb M, Gaber AO, Gaber L. Quantitative detection of T-cell activation markers by real-time PCR in renal transplant rejection and correlation with histopathologic evaluation.
Transplantation. 2002 Sep 15;74(5):701-7. |
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