• A novel regulatory mechanism for human interferon lambda has been defined

  • A new graduate student begins her work towards an M.S. at HUMIGEN, graduation expected 2013

  • HUMIGEN opens two new research laboratories, in Lymphocyte Signaling and Cellular Immunology

  • HUMIGEN begins recruiting SLE patients for a novel biomarker discovery study

  • A HUMIGEN Research Associate graduates May 2011 with an M.S. in Molecular Pathology and Immunology

  • HUMIGEN begins recruiting asthma patients for a novel biomarker discovery study

  • A new soluble variant of the human IL-23 receptor inhibits the development of human Th17 cells

  • Two graduate students are working towards their M.S. in HUMIGEN, graduation expected 2012

  • HUMIGEN begins recruiting IBD patients for a novel biomarker discovery study

  • A novel feedback loop between the Th2 response and interferon lambda is mediated by monocytes

  • A new Ph.D. student begins work in HUMIGEN research laboratories

Home Research Laboratories Clinical Studies Publications Abstracts & Presentations Collaboration Careers M.S. Program Delta – 9 Genesis

Publications


Regulation of IFN-λ1 Promoter Activity (IFN-λ1/IL-29) in Human Airway Epithelial Cells. Siegel R, Eskdale J, Gallagher G. J Immunol. 2011 Dec 1;187(11):5636-44. Epub 2011 Nov 4. PMID:    22058416  

A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells. Yu RY, Gallagher G. J Immunol. 2010 Dec 15;185(12):7302-8. Epub 2010 Nov 12. PMID:    21076058  

Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk. Morrison BA, Ucisik-Akkaya E, Flores H, Alaez C, Gorodezky C, Dorak MT. Autoimmunity. 2010 Dec;43(8):690-7. PMID:    21067287  

Interleukin-19: multiple roles in immune regulation and disease. Gallagher G. Cytokine Growth Factor Rev. 2010 Oct;21(5):345-52. Review. PMID:    20889366  

Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection Ucsik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Dorak MT. Mol Hum Reprod. 2010 Oct;16(10):770-7. Epub 2010 Jun 29. PMID:    20587610  

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility. Ucisik-Akkaya E, Davis CF, Gorodezky C, Alaez C, Dorak MT. Cell Stress Chaperones. 2010 Sep;15(5):475-85. Epub 2009 Dec 9. PMID:    20012387  

The lambda interferons: guardians of the immune-epithelial interface and the T-helper 2 response. Gallagher G, Megjugorac NJ, Yu RY, Eskdale J, Gallagher GE, Siegel R, Tollar E. J Interferon Cytokine Res. 2010 Aug;30(8):603-15. PMID:    20712455  

IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra. Megjugorac NJ, Gallagher GE, Gallagher G. Blood. 2010 May 27;115(21):4185-90. Epub 2010 Mar 16. PMID:    20233967  

An intronic polymorphism of IRF4 gene influences gene transcription in vitro and shows a risk association with childhood acute lymphoblastic leukemia in males. Do TN, Ucisik-Akkaya E, Davis CF, Morrison BA, Dorak MT. Biochim Biophys Acta. 2010 Feb;1802(2):292-300. Epub 2009 Nov 6. PMID:    19897031  

An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia. Davis CF, Dorak MT. Ann Hematol. 2010 Apr;89(4):375-84. Epub 2009 Oct 6. PMID:    19806355  

Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29). Megjugorac NJ, Gallagher GE, Gallagher G. J Leukoc Biol. 2009 Dec;86(6):1359-63. Epub 2009 Sep 16. PMID:    19759281  

TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility. Do TN, Ucisik-Akkaya E, Davis CF, Morrison BA, Dorak MT. Cancer Genet Cytogenet. 2009 Nov;195(1):31-6. PMID:    19837266  

IFN-lambda1 (IL-29) inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells. Dai J, Megjugorac NJ, Gallagher GE, Yu RY, Gallagher G. Blood. 2009 Jun 4;113(23):5829-38. Epub 2009 Apr 3. PMID:    19346497  

A study of natural killer cell lectin-like receptor K1 gene (KLRK1/NKG2D) region polymorphisms in a European population sample. Ucisik-Akkaya E, Dorak MT. Tissue Antigens. 2009 Feb;73(2):177-83. PMID:    19140827  

Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro. Srinivas S, Dai J, Eskdale J, Gallagher GE, Megjugorac NJ, Gallagher G. Immunology. 2008 Dec;125(4):492-502. Epub 2008 Jun 10. PMID:    18547367  

Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes. Kan SH, Mancini G, Gallagher G. Genes Immun. 2008 Oct;9(7):631-9. Epub 2008 Aug 28. PMID:    18754016  

A novel insertion variant of the human IL-23 receptor-alpha chain transcript. Mancini G, Kan SH, Gallagher G. Genes Immun. 2008 Sep;9(6):566-9. Epub 2008 Jul 10. PMID:    18615094  

Human interferon lambda-1 (IFN-lambda1/IL-29) modulates the Th1/Th2 response. Jordan WJ, Eskdale J, Srinivas S, Pekarek V, Kelner D, Rodia M, Gallagher G. Genes Immun. 2007 Apr;8(3):254-61. Epub 2007 Mar 15. PMID:    17361203  

Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. Pekarek V, Srinivas S, Eskdale J, Gallagher G. Genes Immun. 2007 Mar;8(2):177-80. Epub 2007 Jan 25. PMID:    17252004  

Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29). Jordan WJ, Eskdale J, Boniotto M, Rodia M, Kellner D, Gallagher G. Genes Immun. 2007 Jan;8(1):13-20. Epub 2006 Nov 2. PMID:    17082759